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. 2022 Apr 1;12:5508. doi: 10.1038/s41598-022-09421-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heat maps of anxiety scores and circadian phenotypes. (A,B) Higher anxiety scores indicative of severe anxiety are strongly associated with positive PER3 phase (advanced circadian phase or morning-types) and high circadian amplitude. (C,D) Similar patterns are seen with circadian phenotypes measured using the NR1D2 phase and amplitude. The heatmaps were made using Fisher’s Exact Test at varying cutoff levels for both dependent and independent variables. The p-values obtained from the analysis were log-transformed (base 10).