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. 2022 Apr 1;12:5508. doi: 10.1038/s41598-022-09421-4

Table 1.

Risk factors for anxiety symptoms.

Variable Odds ratio 95% CI Adj P
PER3B_AG/CRY1_CG 15.262 2.352–319.019 0.026
PER3B_AG/CRY2_AA 0.17 0.034–0.694 0.026
AGE 3.851 1.234–14.006 0.031
CLOCK3111_TC/CRY2_AG 2.524 1.226–5.761 0.026
CRY1_CC/PER3_VNTR_4,4 2.432 1.029–6.781 0.061
GENDER 1.826 1.121–2.972 0.026
MEQ 0.958 0.935–0.982 0.005

Results from a multivariate logistic regression model based on top-ranked selected features identify two-way gene combinations, most notably PER3B-AG/CRY1-CG, as well as demographic features that are strongly associated with anxiety symptoms. Age is coded as 1 for 18–22 years old and 0 for > 22 years old. Gender is coded as 1 for females, and 0 for males.