Fig. 2.

In vivo recovery of CMV-specific immunity in humanized mice after CMV-CTL therapy. A Recovery of CMV-CTLs in donor and third-party CMV-CTL-infused mice and control mice. B Persistence and expansion of CFSE⁺ CD8⁺ T cells (adoptively transferred CMV-CTLs) in PB after CMV-CTL infusion. C Change in PD-1 expression of CD8⁺ T cells in donor and third-party CMV-CTL-infused mice and control mice. D CFSE⁺ CD8⁺ T cells (adoptively transferred CMV-CTLs) in the PB of transplant donor and third-party CMV-CTL-infused mice from Day 2 to Day 28. No fewer than five mice were evaluated at each time point. Transplant donor and third-party CMV-CTL group vs. control group, *P < 0.05, **P < 0.01