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. 2022 Apr 1;13:1752. doi: 10.1038/s41467-022-29346-w

Table 1.

Comparison of results in this study to previously published screens13,1517,19,20.

Study Hits Genes targeted Hit rate Gene list description Technology Pooled or arrayed Cell type
Yeung et al. 252 54509 0.46% 54,509 human transcripts, including ESTs shRNA Pooled Jurkat
Brass et al. 386 21,121 1.83% 21,121 pools of 4 siRNAs per gene (genome wide) siRNA Arrayed TZM-bl
Konig et al. 294 20000 1.47% arrayed genome-wide siRNA library targeting ∼20,000 human genes siRNA Arrayed 293 T
Zhou et al. 311 19709 1.58% siRNA library targeting 19,709 genes with pools of 3 siRNAs per gene siRNA Arrayed HeLa P4/R5
OhAinle et al. 15 1905 0.79% Interferon-stimulated genes in cell types relevant to HIV infection CRISPR Pooled THP-1
Park et al. 5 18543 0.03% Genome-wide protein-coding genes CRISPR Pooled GXRCas9 T cell line
Hiatt et al. 47 426 11.03% HIV interactome (Jager et al.) CRISPR RNPs Arrayed Primary human CD4+ T cells

Bold values reflect the number of hits over the number of genes targeted as indicated.