Table 1.
Study | Hits | Genes targeted | Hit rate | Gene list description | Technology | Pooled or arrayed | Cell type |
---|---|---|---|---|---|---|---|
Yeung et al. | 252 | 54509 | 0.46% | 54,509 human transcripts, including ESTs | shRNA | Pooled | Jurkat |
Brass et al. | 386 | 21,121 | 1.83% | 21,121 pools of 4 siRNAs per gene (genome wide) | siRNA | Arrayed | TZM-bl |
Konig et al. | 294 | 20000 | 1.47% | arrayed genome-wide siRNA library targeting ∼20,000 human genes | siRNA | Arrayed | 293 T |
Zhou et al. | 311 | 19709 | 1.58% | siRNA library targeting 19,709 genes with pools of 3 siRNAs per gene | siRNA | Arrayed | HeLa P4/R5 |
OhAinle et al. | 15 | 1905 | 0.79% | Interferon-stimulated genes in cell types relevant to HIV infection | CRISPR | Pooled | THP-1 |
Park et al. | 5 | 18543 | 0.03% | Genome-wide protein-coding genes | CRISPR | Pooled | GXRCas9 T cell line |
Hiatt et al. | 47 | 426 | 11.03% | HIV interactome (Jager et al.) | CRISPR RNPs | Arrayed | Primary human CD4+ T cells |
Bold values reflect the number of hits over the number of genes targeted as indicated.