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. 2021 Jul 16;43(4):829–839. doi: 10.1038/s41401-021-00727-z

Fig. 4. SFN administration is associated with changed Nrf2 and MeCP2 abnormal expression in microglia of stressed mice.

Fig. 4

a SFN suppresses stress-induced upregulation of IBA1 positive microglia, which is associated with increased Nrf2 in IBA1 positive microglia. Representative images of Nrf2 expression in IBA1 positive microglia in the mPFC assayed by immunofluorescence staining. b SFN suppresses stress-induced upregulation of IBA1 positive microglia, which is associated with decreased MeCP2 expression in IBA1 positive microglia. Representative images of MeCP2 expression in IBA1 positive microglia in the mPFC assayed by immunofluorescence staining. Scale bar, 50 μm. Quantification of IBA1 (c and d) immunoreactivity, Nrf2 (e) and MeCP2 (f) fluorescence intensity (Mean ± SEM, n = 4 per group, one-way ANOVA, *P < 0.05, **P < 0.01, and ***P < 0.001).