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. 2021 Jul 16;43(4):829–839. doi: 10.1038/s41401-021-00727-z

Fig. 6. SFN stimulates stress-induced downregulation of Arginase1 positive microglia, associated with changed Nrf2 and MeCP2 abnormal expression in microglia with anti-inflammatory phenotype in stressed mice.

Fig. 6

a SFN enhances stress-induced downregulation of Arginase1 positive microglia, which is associated with increased Nrf2 expression in Arginase1 positive microglia. Representative images of Arginase1 and Nrf2 in the mPFC of stressed mice. Representative positive stainings are indicated by arrows. Scale bar, 50 μm. b SFN enhances stress-induced downregulation of Arginase1 positive microglia, which is associated with decreased MeCP2 expression in Arginase1 positive microglia. Representative images of Arginase1 and MeCP2 in the mPFC of stressed mice. Representative positive stainings are indicated by arrows. Scale bar, 50 μm. Quantification of Arginase1 (c), Nrf2 (d), and MeCP2 (e) fluorescent intensity in the Arginase1 positive microglia (Mean ± SEM, n = 4 per group, one-way ANOVA, **P < 0.01, ***P < 0.001).