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. 2021 Jul 15;43(4):1013–1023. doi: 10.1038/s41401-021-00718-0

Fig. 4. Antitumor effect of WZ-2-033 in the MGC-803 mouse xenograft model.

Fig. 4

a MGC-803 xenograft mice were administered 5 or 15 mg/kg WZ-2-033 or vehicle (15% Cremophor EL in PBS) via i.p. injection per day. The tumor size was measured every 3 days. Values are presented as the mean ± SEM. n = 10. b Tumor weight after 30 days of administration. Values are presented as the mean ± SEM. n = 10. *P < 0.05; **P < 0.01 vs the vehicle group. c Representative images of gastric cancer xenografts. d pY705-STAT3, STAT3, Bcl-2, Bcl-xL, c-myc, and Mcl-1 immunoblots for tumor tissue lysates from three different vehicle- and WZ-2-033-treated mice. e IHC for Ki-67 and pY705-STAT3 in the tumor tissues of vehicle- and WZ-2-033-treated mice. Scale bar = 100 μm