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. 2022 Mar 28;14:395–404. doi: 10.2147/IJWH.S352167

Table 1.

Menstrual Symptoms Post-Vaccination and During COVID-19 Pandemic n (%)

Post-Vaccination During COVID-19 Pandemic p value
First Dose Only Second Dose Only Both Doses
Irregular menstruation 319 (14.1) 212 (9.3) 149 (6.6) 278 (12.3) <0.001
Menstrual cramps 214 (9.4) 151 (6.7) 98 (4.3) 444 (19.6) <0.001
Increased period frequency 197 (8.7) 146 (6.4) 103 (4.5) 172 (7.6) <0.001
Menorrhagia 201 (8.9) 145 (5.4) 78 (3.4) 170 (7.5) <0.001
Increase duration of the menstruation 193 (8.5) 133 (5.9) 70 (3.1) 158 (6.8) <0.001
Menstruation has stopped 78 (3.4) 41 (1.8) 32 (1.4) 39 (1.7) <0.001
Worsening of premenstrual symptoms 38 (1.7) 30 (1.3) 21 (0.9) 115 (5.1) <0.001
Intermenstrual bleeding 26 (1.1) 9 (0.4) 13 (0.6) 62 (2.7) <0.001

Notes: p value was calculated using a chi-squared test and indicates the associations between the menstrual symptoms post-vaccination in total (after the first dose only, second dose only, and after both doses) and menstrual symptoms during the COVID-19 pandemic.