Table 3.
Multiple Regression Analysis of Oxidation, Glycation, and Carbamylation of Salivary and Plasma Proteins, Lipids, and DNA
| β1: Age | β2: Sex | ||||||
|---|---|---|---|---|---|---|---|
| Estimate | 95% CI | p-value | Estimate | 95% CI | p-value | ||
| Saliva | Total thiols level | −0.4503 | −0.5855 - −0.3151 | < 0.0001 | −1.344 | −8.958–6.27 | 0.728 |
| Protein carbonyls level | 0.02077 | 0.01454–0.027 | < 0.0001 | 0.06285 | −0.2879–0.4136 | 0.7241 | |
| MGO level | 0.008252 | 0.002732–0.01377 | 0.0036 | 0.03345 | −0.2773–0.3442 | 0.8321 | |
| CML level | 0.6253 | 0.4453–0.8053 | < 0.0001 | 12.34 | 2.204–22.47 | 0.0173 | |
| AGE level | 0.01658 | 0.01334–0.01982 | < 0.0001 | 0.2036 | 0.02129–0.3859 | 0.0288 | |
| CBL level | 0.01539 | 0.01067–0.02012 | < 0.0001 | −0.1421 | −0.4083–0.124 | 0.2934 | |
| 4-HNE level | 0.01584 | 0.01141–0.02026 | < 0.0001 | −0.05109 | −0.3003–0.1981 | 0.6863 | |
| 8-OHdG level | 0.02196 | 0.01783–0.02608 | < 0.0001 | −0.154 | −0.3862–0.07826 | 0.1924 | |
| Plasma | Total thiols level | −0.1152 | −0.1491 - −0.08128 | < 0.0001 | −0.2048 | −2.115–1.706 | 0.8327 |
| Protein carbonyls level | 0.09016 | 0.0628–0.1175 | < 0.0001 | −0.08927 | −1.63–1.452 | 0.9091 | |
| MGO level | 0.09579 | 0.0738–0.1178 | < 0.0001 | 0.5817 | −0.6561–1.82 | 0.355 | |
| CML level | 0.9321 | 0.6263–1.238 | < 0.0001 | 3.591 | −13.63–20.81 | 0.6812 | |
| AGE level | 0.01235 | 0.009662–0.01505 | < 0.0001 | −0.055 | −0.2066–0.0966 | 0.475 | |
| CBL level | 0.06489 | 0.04654–0.08325 | < 0.0001 | −1.139 | −2.173 - −0.106 | 0.0309 | |
| 4-HNE level | 0.03569 | 0.02855–0.04283 | < 0.0001 | −0.01329 | −0.4153–0.3887 | 0.948 | |
| 8-OHdG level | 0.02633 | 0.02141–0.03125 | < 0.0001 | −0.02482 | −0.302–0.2523 | 0.8599 | |
Abbreviations: AGE, advanced glycation end products; CBL, carbamyl-lysine; CI, confidence interval; CML, Nε-(carboxymethyl) lysine; MGO, methylglyoxal adducts; 4-HNE, 4-hydroxynonenal protein adducts; 8-OHdG, 8-hydroxy-2’-deoxyguanosine.