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Schematic illustration for fabrication of CAp HCGs and animal experiments. (a) Extrusion of HC green bodies, (b) cutting of the HC green bodies (c) to obtain HC green body granules. (d) Heat treatment of the HC green body granules to obtain CaCO3 HCGs via debinding and sintering. (e) Phosphatization of CaCO3 HCGs by immersing them in an Na2HPO4 solution (f) to obtain CAp HCGs. (g) Implantation of CAp HCGs and DGs into a critical size bone defect produced in the rabbit femur condyle.
