. 2022 Mar 29;27:101781. doi: 10.1016/j.pmedr.2022.101781

Table 2.

Factors associated with high risk cancer genetic testing (N = 2265, representing 158,364,845 in weighted).

Variable	Categories	Unadjusted model			Adjusted model
Variable	Categories	OR	95% CI	P	OR	95% CI	P
Cancer worry¹	Not at all or Slightly	ref
	Somewhat	2.72	1.47–5.01	0.002	2.37	1.12–5.01	0.025
	Extremely or Moderately	5.84	2.87–11.86	less than0.001	4.78	2.19–10.43	less than0.001
Perceived genetic susceptibility²	A little or Not at all	ref
Perceived genetic susceptibility²	A lot or Somewhat	3.81	0.86–16.80	0.076	2.38	0.55–10.24	0.239
Importance of genetics for cancer prevention³	A little or Not at all	ref
Importance of genetics for cancer prevention³	Very or Somewhat	2.86	0.82–9.98	0.097	0.78	0.19–3.29	0.735
Importance of genetics for early detection of cancer³	A little or Not at all	ref
Importance of genetics for early detection of cancer³	Very or Somewhat	8.26	1.65–41.25	0.011	18.03	4.07–79.79	less than0.001
Fatalistic belief⁴	Strongly/Somewhat disagree	ref
Fatalistic belief⁴	Strongly/Somewhat agree	0.83	0.43–1.59	0.572	0.82	0.41–1.63	0.564
Prevention not possible⁵	Strongly/Somewhat disagree	ref
Prevention not possible⁵	Strongly/Somewhat agree	0.68	0.35–1.35	0.265	0.68	0.27–1.72	0.403
Too many recommendations⁶	Strongly/Somewhat disagree	ref
Too many recommendations⁶	Strongly/Somewhat agree	0.98	0.52–1.86	0.943	0.82	0.36–1.89	0.639
Self-efficacy⁷	Strongly/Somewhat disagree	ref
Self-efficacy⁷	Strongly/Somewhat agree	0.69	0.29–1.67	0.405	0.45	0.17–1.18	0.102
Desire to know about mutation status⁸	A little or Not at all	ref
Desire to know about mutation status⁸	A lot or Somewhat	2.36	0.89–6.30	0.084	1.85	0.77–4.43	0.165
Personal history of cancer	No	ref
	Breast/ovarian/Colorectal cancer	52.20	24.16–112.80	less than0.001	28.38	10.19–79.04	less than0.001
	Other cancer	1.30	0.63–2.68	0.469	0.69	0.31–1.52	0.346
Family history of cancer	No/Not sure	ref
Family history of cancer	Yes	3.59	1.46–8.81	0.006	2.43	0.77–7.64	0.127
Age	Age	1.02	1.01–1.03	0.002	1.02	1.00–1.03	0.085
Sex	Male	ref
Sex	Female	4.14	2.23–7.70	less than0.001	2.97	1.41–6.26	0.005
Race/Ethnicity	NH White	ref
	NH Black	0.63	0.25–1.54	0.302	0.75	0.19–3.02	0.679
	Hispanic	0.39	0.18–0.82	0.014	0.37	0.16–0.86	0.022
	NH Asian	0.12	0.01–2.43	0.162	0.12	0.04–0.33	less than0.001
	NH Other	0.79	0.22–2.81	0.705	1.30	0.21–8.17	0.775
Education	Less than high school	ref
	12 years or completed high school	0.78	0.22–2.76	0.688	0.38	0.08–1.80	0.218
	Some college	0.78	0.25–2.49	0.674	0.33	0.08–1.42	0.133
	College graduate or higher	0.70	0.28–1.76	0.436	0.33	0.09–1.23	0.098
Income	Less than 20,000
	20,000 to less than 35,000	0.33	0.11–0.98	0.046	0.31	0.07–1.37	0.120
	35,000 to less than 50,000	0.86	0.26–2.83	0.799	0.83	0.18–3.82	0.809
	50,000 to less than 75,000	1.38	0.51–3.73	0.524	1.76	0.60–5.21	0.300
	75,000 or more	1.02	0.46–2.24	0.962	1.27	0.41–3.88	0.673

OR: Odds ratio; NH: Non-Hispanic; ¹How worried are you about getting cancer?; ²How much do you think genes that are inherited determine whether or not a person will develop [cancer]?; ³How important is knowing a person’s genetic information for: a) preventing cancer; and, b) detecting cancer early; ⁴It seems like everything causes cancer; ⁵There’s not much you can do to lower your chances of getting cancer; ⁶There are so many different recommendations about preventing cancer, it’s hard to know which ones to follow; ⁷If I found out from a genetic test that I was at high risk of cancer, I would change my behaviors such as diet, exercise and getting routine medical tests; ⁸How much would you want to know if you have a genetic change that increases your chances of getting cancer?