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A proposed model for the regulatory mechanism of rs2069837 on the expression of IL6 involved in COVID-19. There was higher expression of MEF2 expression and lower GPNMB expression in IL6 rs2069837 AA genotype group, leading to IL6 up-regulation and severe COVID-19 development. IL6 rs2069837 GG genotype could decrease MEF2a binding and increase GPNMB expression, resulting in lower IL6 expression and prevention of severe COVID-19
