Table 2.

Effects of interventions on mean blood pressure across the whole trial, N = 975 participants (13,925 study visits for systolic blood pressure and 12,924 visits for diastolic blood pressure)

	Change in systolic blood pressure, mm Hg		Change in diastolic blood pressure, mm Hg
	β (95% CI)	P	β (95% CI)	P
All groups
Usual care	Reference	—	Reference	—
Weight loss	−2.46 (−4.55, −0.37)	0.021	−0.98 (−2.50, 0.54)	0.21
Sodium reduction	−1.79 (−3.44, −0.14)	0.034	−0.50 (−1.50, 0.50)	0.33
Weight loss and sodium reduction	−4.33 (−6.48, −2.17)	<0.001	−2.47 (−3.88, −1.06)	0.001
Factorial design—weight loss
No weight lossa	Reference	—	Reference	—
Weight loss	−2.49 (−4.00, −0.98)	0.001	−1.48 (−2.51, −0.44)	0.005
Factorial design—sodium reduction
No sodium reductiona	Reference	—	Reference	—
Sodium reduction	−1.81 (−3.20, −0.42)	0.011	−0.79 (−1.68, 0.09)	0.08

Change in follow-up blood pressure was modeled using a generalized estimating equation adjusted for baseline obesity status, field center, and baseline systolic or diastolic blood pressure. Interaction terms between weight loss and sodium reduction were nonsignificant. Abbreviation: CI, confidence interval.

^aNo weight loss includes usual care and sodium reduction. No sodium reduction includes usual care and weight loss.