Table 4.

Effect of randomized intervention on self-reported orthostatic symptoms^a

	Lightheadedness, N = 556 instances	Faint, N = 186 instances	Imbalance, N = 513 instances	Combination, N = 843 instances
	OR (95% CI)b	OR (95% CI)b	OR (95% CI)b	OR (95% CI)b
All groups
Usual care	Reference	Reference	Reference	Reference
Weight loss	1.23 (0.70, 2.16)	0.62 (0.22, 1.74)	0.88 (0.56, 1.40)	0.89 (0.59, 1.33)
Sodium reduction	1.07 (0.72, 1.58)	0.42 (0.20, 0.87)	0.84 (0.58, 1.21)	0.87 (0.62, 1.21)
Weight loss and sodium reduction	0.59 (0.37, 0.93)	0.22 (0.09, 0.58)	0.70 (0.43, 1.14)	0.62 (0.41, 0.92)
Factorial design—weight loss
No weight lossc	Reference	Reference	Reference	Reference
Weight loss	0.78 (0.55, 1.12)	0.58 (0.31, 1.09)	0.86 (0.62, 1.20)	0.79 (0.60, 1.04)
Factorial design—sodium reduction
No sodium reductionc	Reference	Reference	Reference	Reference
Sodium reduction	0.86 (0.62, 1.20)	0.41 (0.23, 0.75)	0.83 (0.61, 1.12)	0.81 (0.62, 1.06)

Interaction terms between weight loss and sodium reduction were nonsignificant. Abbreviations: CI, confidence interval; OR, odds ratio.

^a N = 975 participants with 4,842 visits for lightheadedness, 4,841 visits for faint, 4,833 visits for imbalance, and 4,843 visits for any combination of symptoms.

^bOdds of symptoms were modeled using generalized estimating equations, adjusted for baseline obesity status, field center, and baseline symptom corresponding to the outcome (i.e., lightheadedness, faint, imbalance, or the combination).

^cNo weight loss includes usual care and sodium reduction. No sodium reduction includes usual care and weight loss.