表 1.
EGFR、ALK基因组基线数据及影像学、病理学特征对比
Comparison of baseline data and imaging and pathological features of patients with EGFR and ALK gene mutation group and wild group
| Characteristics | EGFR mutation status | OR | P | ALK mutation status | OR | P | ||
| Yes (n=314) | No (n=211) | Yes (n=17) | No (n=508) | |||||
| CTR: consolidation tumor ratio; LN: lymph nodes; VPI: visceral pleural invasion; EGFR: epidermal growth factor receptor; ALK: anaplastic lymphoma kinase; BMI: body mass index; TNM: tumor-node-metastasis. | ||||||||
| Age (yr) | 58.65±10.81 | 56.86±11.38 | 0.069 | 49.77±13.58 | 58.20±10.89 | 0.002 | ||
| Gender [n (%)] | 0.569 | 0.007 | 1.424 | 0.718 | ||||
| Male | 59 (18.8) | 61 (28.9) | 5 (29.4) | 115 (22.6) | ||||
| Female | 255 (81.2) | 150 (71.1) | 12 (70.6) | 393 (77.4) | ||||
| Smoking history [n (%)] | 0.625 | 0.055 | 3.303 | 0.039 | ||||
| Yes | 39 (12.4) | 39 (18.5) | 6 (35.3) | 72 (14.2) | ||||
| No | 275 (87.6) | 172 (81.5) | 11 (64.7) | 436 (85.8) | ||||
| BMI (mg/m2) | 23.45±3.32 | 23.36±2.74 | 0.737 | 22.70±4.01 | 23.44±3.07 | 0.337 | ||
| TNM [n (%)] | 0.085 | 0.130 | ||||||
| Ia+Ib | 282 (89.8) | 196 (92.9) | 14 (82.4) | 464 (91.3) | ||||
| IIa+IIb | 16 (5.1) | 12 (5.7) | 1 (5.9) | 27 (5.3) | ||||
| IIIa | 16 (5.1) | 3 (1.4) | 2 (11.7) | 17 (3.4) | ||||
| Radiological features | ||||||||
| Tumor diameter (cm) | 1.98±0.93 | 1.75±0.95 | 0.008 | 1.98±1.68 | 1.89±0.91 | 0.817 | ||
| Solid component diameter (cm) | 1.28±1.01 | 1.03±0.95 | 0.004 | 1.60±1.87 | 1.16±0.95 | 0.356 | ||
| CTR | 0.61±0.34 | 0.55±0.35 | 0.052 | 0.72±0.36 | 0.58±0.34 | 0.114 | ||
| CTR≥0.5 [n (%)] | 196 (62.4) | 110 (52.1) | 1.525 | 0.019 | 12 (70.6) | 294 (57.9) | 1.747 | 0.296 |
| Lobulated border [n (%)] | 289 (92.0) | 182 (86.3) | 1.842 | 0.032 | 14 (82.4) | 457 (90.0) | 0.521 | 0.542 |
| Spiculated margin [n (%)] | 304 (96.8) | 205(97.2) | 0.890 | 0.824 | 16 (94.1) | 493 (97.0) | 0.487 | 0.414 |
| Air bronchogram [n (%)] | 159 (41.1) | 102 (48.3) | 1.096 | 0.606 | 6 (35.3) | 255 (50.2) | 0.541 | 0.227 |
| Pleural retraction [n (%)] | 207 (65.9) | 109 (51.7) | 1.810 | 0.001 | 10 (58.8) | 306 (60.2) | 0.943 | 0.907 |
| Bubble-like lucency [n (%)] | 53 (16.9) | 43 (20.4) | 0.793 | 0.309 | 5 (29.4) | 91 (17.9) | 1.909 | 0.375 |
| Histology subtype [n (%)] | ||||||||
| Lepidic | 192 (61.1) | 138 (65.4) | 0.833 | 0.322 | 5 (29.4) | 325 (64.0) | 0.235 | 0.004 |
| Acinar | 283 (90.1) | 177 (83.9) | 1.754 | 0.033 | 14 (82.4) | 446 (87.8) | 0.649 | 0.767 |
| Papillary | 92 (29.3) | 47 (22.3) | 1.446 | 0.074 | 4 (23.5) | 135 (26.6) | 0.850 | > 0.999 |
| Micropapillary | 23 (7.3) | 12 (5.7) | 1.311 | 0.461 | 5 (29.4) | 30 (5.9) | 6.639 | 0.001 |
| Solid | 33 (10.5) | 22 (10.4) | 1.009 | 0.976 | 2 (11.8) | 53 (10.4) | 1.145 | > 0.999 |
| LN metastasis [n (%)] | 20 (6.4) | 10 (4.7) | 1.367 | 0.430 | 2 (11.8) | 28 (5.5) | 2.286 | 0.253 |
| VPI [n (%)] | 30 (9.6) | 13 (6.2) | 1.609 | 0.165 | 5 (29.4) | 38 (7.5) | 5.154 | 0.005 |