表 2.
EGFR基因突变亚型分层分析及组内对照分析
Stratification analysis and intra-group control analysis of EGFR gene mutation subtype
| Characteristics | EGFR wild type (n=211) | EGFR mutated | P | |
| Exon 19 (n=111) | Exon 21 (n=176) | |||
| a: EGFR wild type group vs exon 19 mutation group; b: EGFR exon 19 mutation group vs exon 21 mutation group; c: EGFR wild type group vs exon 21 mutation group. | ||||
| Age (yr) | 56.86±0.78 | 57.13±1.05 | 60.19±0.77 | 0.007b, c |
| Gender [n (%)] | 0.023a, c | |||
| Male | 61 (28.9) | 21 (18.9) | 32 (18.2) | |
| Female | 150 (71.1) | 90 (81.1) | 144 (81.8) | |
| Smoking history [n (%)] | 0.146 | |||
| Yes | 172 (81.5) | 95 (85.6) | 156 (88.6) | |
| No | 39 (18.5) | 16 (14.4) | 20 (11.4) | |
| Radiological characteristics | ||||
| Tumor diameter (cm) | 1.76±0.07 | 1.86±0.08 | 2.00±0.07 | 0.034c |
| Solidcomponent diameter (cm) | 1.03±0.07 | 1.34±0.09 | 1.20±0.08 | 0.019a |
| CTR | 0.55±0.02 | 0.69±0.03 | 0.55±0.03 | 0.001a, b |
| CTR≥0.5 [n (%)] | 110 (52.1) | 83 (74.8) | 96 (54.5) | 0.001a, b |
| Lobulated border [n (%)] | 182 (86.3) | 104 (93.7) | 163 (92.6) | 0.041a, c |
| Spiculated margin [n (%)] | 205 (97.2) | 106 (95.5) | 172 (97.7) | 0.550 |
| Pleural retraction [n (%)] | 109 (51.7) | 73 (65.8) | 116 (65.9) | 0.006a, c |
| Air bronchogram [n (%)] | 102 (48.3) | 54 (48.6) | 93 (52.8) | 0.644 |
| Bubble-like lucency [n (%)] | 43 (20.4) | 22 (19.8) | 27 (15.3) | 0.409 |
| Histological subtype [n (%)] | ||||
| Lepidic | 138 (65.4) | 62 (55.9) | 117 (66.5) | 0.149 |
| Acinar | 177 (83.9) | 102 (91.9) | 158 (89.8) | 0.068 |
| Papillary | 47 (22.3) | 36 (32.4) | 42 (23.9) | 0.122 |
| Micropapillary | 12 (5.7) | 10 (9.0) | 10 (5.7) | 0.453 |
| Solid | 22 (10.4) | 10 (9.0) | 20 (11.4) | 0.817 |
| LN metastasis [n (%)] | 10 (4.7) | 9 (8.1) | 8 (4.5) | 0.365 |
| VPI [n (%)] | 13 (6.2) | 11 (9.9) | 15 (8.5) | 0.450 |