Table 3.

Summary of adverse events and adherence across studies.

Study	Adverse events		Adherence
	Safety management	Number of adverse events	Adherence management	Dropout rate, n (%)	Reasons for dropout
Alves da Cruz et al, 2020 [18]	Control exercise intensity	Cardiac, 0 Musculoskeletal, 0	NRa	0	NR
Jaarsma et al, 2020 [20]	Instruction for adapting active video games Phone consultation	Cardiac, 0 Musculoskeletal, 0	Motivational calls	71 (23%)	Medical-related issues Practical logistic reasons Refusal to continue Loss to follow-up Death
Klompstra et al, 2013 [21]	Safety guideline Phone call to heart failure nurse	Cardiac, 0 Musculoskeletal, 0	Remote guidance Follow-up visits	0	NR
Klompstra et al, 2014 [22]	Safety guideline Phone call to heart failure nurse	Cardiac, 0 Musculoskeletal, 1 (myalgia)	Telephone guidance	1 (3%)	Moved abroad for work
Ruivo et al, 2017 [19]	Playing active video games within individual target heart rate zones (55%-70%) Safety guideline Supervision at all times Monitoring by telemetry	Cardiac, 0 Musculoskeletal, 1 (osteoarthritic knee pain)	Motivational calls	1 (6.3%)	Returned to work

^aNR: not reported.