Table 1.

Group demographics and study characteristics

Author, Year	No. of Ankles	Intervention	Comparator(s)	Average Age ± SD	Average Follow-Up	LOE	MQOE
Gormeli et al., 2015 [41]	40	MF/HA group Arthroscopic MF and subsequent HA injection	MF/PRP group Arthroscopic MF and subsequent PRP injection MF/saline group Arthroscopic MF and subsequent saline injection	MF/HA group 39.7 ± 8.7 years MF/PRP group 38.6 ± 9.1 years MF/saline group 40.3 ± 9.4 years	15.3 months (range, 11–25)	1	81
Doral et al., 2012 [43]	57	MF/HA group Arthroscopic MF and subsequent weekly HA injection for three weeks	MF group Arthroscopic MF alone	MF/HA group Not reported MF group Not reported Combined 40.5 ± 13.0 years	≥24 months	2	83
Shang et al., 2016 [42]	35	MF/HA group Arthroscopic MF and subsequent weekly HA injection for three weeks	MF group Arthroscopic MF alone	MF/HA group 34.7 ± 8.7 years MF group 36.6 ± 10.7 years	MF/HA group 10.4 months (SD, 1.3) MF group 10.7 months (SD, 1.1)	1	77

Abbreviations: SD Standard deviation, LOE Level of evidence, MQOE Methodological quality of evidence, MF Microfracture surgery, HA Hyaluronic acid, PRP Plate-rich plasma