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. 2022 Apr 2;21:93. doi: 10.1186/s12943-022-01537-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Clinical implications of circMAP3K4 expression in HCC. A CircMAP3K4 expression in HCC (n = 39) and liver tissues (n = 39) from Sun Yat-sen University Cancer Center (SYSUCC). B CircMAP3K4 expression in paired HCC and adjacent liver tissues from SYSUCC (n = 39). C Representative H&E and fluorescence in situ hybridization images of circMAP3K4 RNA in HCC at 20 × . D, E The disease-free survival and overall survival of HCC patients with high versus low circMAP3K4 levels in SYSUCC samples. cMAP3K4, circMAP3K4; SYSUCC, Sun Yat-sen University Cancer Center; H&E, hematoxylin–eosin staining; HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval