Table 2.
Correlation of p53 and OCT1 expression with clinicopathological parameters
| Parameter | n | p53WT-ex | p53MT-ex | P-value | OCT1High | OCT1Low | P-value | |
|---|---|---|---|---|---|---|---|---|
| Age (years) | ≥ 65 | 39 | 15 (38.5%) | 24 (61.5%) | 0.799 | 17 (43.6%) | 22 (56.4%) | 0.803 |
| < 65 | 27 | 12 (44.4) | 15 (55.6) | 13 (48.1) | 14 (51.9) | |||
| Sex | Male | 51 | 20 (39.2) | 31 (60.8) | 0.766 | 24 (47.1) | 27 (52.9) | 0.770 |
| Female | 15 | 7 (46.7) | 8 (53.3) | 6 (40.0) | 9 (60.0) | |||
| Tumor location | Upper/middle | 46 | 18 (39.1) | 28 (60.9) | 0.786 | 19 (41.3) | 27 (58.7) | 0.421 |
| Lower/abdominal | 20 | 9 (45.0) | 11 (55.0) | 11 (55.0) | 9 (45.0) | |||
| Histological type | Well/moderate | 54 | 21 (38.9) | 33 (61.1) | 0.528 | 25 (46.3) | 29 (53.7) | 1.000 |
| Poor/basaloid | 12 | 6 (50.0) | 6 (50.0) | 5 (41.7) | 7 (58.3) | |||
| Clinical T factor | cT1/cT2 | 22 | 7 (31.8) | 15 (68.2) | 0.426 | 12 (54.5) | 10 (46.5) | 0.310 |
| cT3/cT4 | 44 | 20 (45.5) | 24 (54.5) | 18 (40.9) | 26 (59.1) | |||
| Clinical N factor | cN0 | 17 | 7 (41.2) | 10 (58.8) | 1.000 | 10 (58.8) | 7 (41.2) | 0.261 |
| cN1–cN4 | 49 | 20 (40.8) | 29 (59.2) | 20 (40.8) | 29 (59.2) | |||
| Clinical stage | II | 18 | 8 (44.4) | 10 (55.6) | 0.783 | 9 (50.0) | 9 (50.0) | 0.783 |
| III/IVa | 48 | 19 (39.6) | 29 (60.4) | 21 (43.8) | 27 (56.2) | |||
| Chemotherapy regimen | CF | 47 | 20 (42.6) | 27 (57.4) | 0.785 | 23 (48.9) | 24 (51.1) | 0.423 |
| DCF | 19 | 7 (36.8) | 12 (63.2) | 7 (36.8) | 12 (64.2) |
CF cisplatin/5-fluorouracil, DCF docetaxel/cisplatin/5-fluorouracil, OCT1 organic cation transporter 1