Table 5.
Correlation of p53 and OCT1 expression with histological response in the CF group
| Parameter | n | Histological response | P-value | ||
|---|---|---|---|---|---|
| Poor | Good | ||||
| Age (years) | ≥ 65 | 30 | 22 (73.3) | 8 (26.7) | 0.722 |
| < 65 | 17 | 14 (82.4) | 3 (17.6) | ||
| Sex | Male | 38 | 30 (78.9) | 8 (21.1) | 0.419 |
| Female | 9 | 6 (66.7) | 3 (33.3) | ||
| Tumor location | Upper/middle | 33 | 27 (81.8) | 6 (18.2) | 0.263 |
| Lower/abdominal | 14 | 9 (64.3) | 5 (35.7) | ||
| Histological type | Well/moderate | 37 | 30 (81.1) | 7 (18.9) | 0.213 |
| Poor/basaloid | 10 | 6 (60.0) | 4 (40.0) | ||
| Clinical T factor | cT1/cT2 | 20 | 17 (85.0) | 3 (15.0) | 0.481 |
| cT3/cT4 | 27 | 20 (74.1) | 7 (25.9) | ||
| Clinical N factor | cN0 | 14 | 12 (85.7) | 2 (14.3) | 0.464 |
| cN1/cN2/cN3 | 33 | 24 (72.7) | 9 (27.3) | ||
| Clinical stage | II | 18 | 15 (83.3) | 3 (16.7) | 0.492 |
| III/IVa | 29 | 21 (72.4) | 8 (27.6) | ||
| p53 expression | Wild type | 20 | 13 (65.0) | 7 (35.0) | 0.165 |
| Mutant type | 27 | 23 (85.2) | 4 (14.8) | ||
| OCT1 expression | High | 23 | 16 (69.6) | 7 (30.4) | 0.318 |
| Low | 24 | 20 (83.3) | 4 (16.7) | ||
| p53/OCT1 expression | Both p53WT-ex and OCT1High | 8 | 3 (37.5) | 5 (62.5) | 0.011* |
| Either p53MT-ex or OCT1Low | 39 | 33 (84.6) | 6 (15.4) | ||
CF cisplatin/5-fluorouracil, OCT1 organic cation transporter 1
*Statistically significant