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. 2022 Apr 2;11:19. doi: 10.1186/s40164-022-00273-2

Fig. 4.

Fig. 4

GPIbα in platelet clearance. Removal of terminal sialic acid from GPIbα O-glycans by neuraminidase leads to an unfolding event of the MSD and additional release of neuraminidases from platelet granules, which desialylate N-glycans on GPIbα. Finally, ADAM17 sheds desialylated GPIbα receptors from the platelet membrane. Platelets with desialylated residues expose galactose and N-acetylgalactosamine that is recognized by the AMR and leads to platelet clearance by hepatocytes and Kupffer cells