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. 2022 Apr 2;11:19. doi: 10.1186/s40164-022-00273-2

Fig. 6.

Fig. 6

Multiple roles of GPIb-IX in immune modulation. GPIb-IX regulates NET formation, bacteria shuttling to the Kupffer cells and uptake by dendritic cells, and is involved in bacteria encasement. GPIb-IX regulates thrombin activity at sites of immune thrombosis, initiates macrophage polarization towards an M1 phenotype, and supports monocyte recruitment to inflammatory endothelial cells. GPIb-IX regulates leukocyte recruitment to the central nervous system which contribute to severity of autoimmune encephalomyelitis