Table 2.
Meta-analysis of two GWASs comprising 784 SLE_ON(+) and 132 603 controls in Japan and Korea
| CHR | POS | rsID | EA/NEA | Gene | Function | EAF | OR [95%CI] | P-value | Phet |
|---|---|---|---|---|---|---|---|---|---|
| Significant in the meta-analysis | |||||||||
| 10 | 14 436 836 | rs7911501 | A/G | MIR4293/MIR1265 | Intergenic | 0.028 | 1.99 [1.59–2.48] | 1.1 × 10−9 | 0.56 |
| 11 | 89 538 685 | rs372605131 | C/T | TRIM49/NAALAD2 | Intronic | 0.089 | 1.65 [1.38–1.98] | 4.8 × 10−8 | 0.21 |
| 13 | 109 491 871 | rs145720245 | A/G | MYO16 | Intronic | 0.006 | 3.91 [2.54–6] | 4.9 × 10−10 | 0.34 |
| Not significant in the meta-analysis | |||||||||
| 6 | 7 236 620 | rs2714333 | T/C | RREB1 | Intronic | 0.015 | 2.76 [1.9–4] | 8.4 × 10−8 | 0.1 |
SLE_ON(+), SLE with S-ONFH; rsID, reference single-nucleotide polymorphism ID; Phet, P heterogeneity among Japanese 2 studies and Korean study.
Rs372605131 locates in intron of TRIM49; however, it is an eQTL of NAALAD2.