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. 2021 Oct 15;31(7):1035–1050. doi: 10.1093/hmg/ddab301

Figure 9.

Figure 9

Kv8.2 KO in an all-cone retina. The all-cone retina mouse strain used here, ‘Conefull’, is the NRL KO combined with an RPE R91W knock-in. (A) Representative ERG traces from the three brightest flashes in the photopic series using the ERG protocol in Figure 8, Conefull: Kv8.2 WT (black) and Conefull: Kv8.2 KO (red). Scale is 200 μV by 40 ms. (B) a wave and (C) b wave amplitude expressed as a function of flash intensity. (C) Hoechst labeling of nuclear layers in retina sections from Conefull: Kv8.2 WT or Conefull: Kv8.2 KO at (D) 2 months or (E) 4 months of age. Scale is 20 μm in (D, E), abbreviations are ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer.