Table 3.
SIMEX estimates for the mixed-effects model of log10 LAM concentration and log10 CFU concentration
| Type | Intercept | log10 LAM Slope (Centered at Median) | Shift for Intercept Day 7 and Day 13 | IIV Intercept (Variance) | Residual Variability |
|---|---|---|---|---|---|
| Observed (Estimated Mixed Effect Parameter) | 5.986 | 0.763 | − 0.806 | 0.271 | 0.480 |
| SIMEX Simulation | 6.038 | 0.795 | − 0.788 | 0.264 | 0.465 |
| Ratio (Observed/ SIMEX) | 0.991 | 0.960 | 1.022 | 1.026 | 1.031 |
CFU, colony-forming units; IIV, interindividual variability; LAM, lipoarabinomannan; log10, 10 logarithm; SIMEX, simulation-extrapolation