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. 2022 Mar 29;16:863–871. doi: 10.2147/DDDT.S354205

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© 2022 Liu et al.

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Clotrimazole inhibits migration and invasion of HCC cells through the ERK pathway. (A and B) The effect of clotrimazole (20μM) alone or combinate with honokiol (10μM) on HuH7 cells migration detected by wound healing assay. (C and D) The effect of clotrimazole (20μM) alone or combinate with honokiol (10μM) on Hep3B cells migration detected by wound healing assay. (E and F) The effect of clotrimazole alone or combinate with honokiol (10μM) on HuH7 cells migration and invasion detected by transwell assay. (G and H) The effect of clotrimazole alone or combinate with honokiol (10μM) on Hep3B cells migration and invasion detected by transwell assay. The results of quantification are expressed as the mean ± SD (n=3), *P<0.05, **P< 0.01, ***P<0.001 vs the control group (without clotrimazole and honokiol group), #P<0.05 vs clotrimazole treated group.