Table E1.
Immunophenotype of predominant antibody deficiency patients
| Variable | IgG subclass deficiency (n = 3) | Specific antibody deficiency (n = 5) | Primary hypogammaglobulinemia (n = 4) | Common variable immunodeficiency (n = 21) | Complicated predominant antibody deficiency (n = 19) | Secondary hypogammaglobulinemia (n = 10) | P |
|---|---|---|---|---|---|---|---|
| Immunoglobulins, mg/dL (mean) | |||||||
| IgG | 662 | 795 | 659 | 465 | 570 | 648 | .38 |
| IgA | 155 | 144 | 158 | 68 | 33 | 320 | <.01 |
| IgM | 74 | 78 | 64 | 26 | 187 | 37 | .08 |
| IgG1 | 334 | 493 | 365 | 281 | 514 | 342 | .27 |
| IgG2 | 259 | 323 | 179 | 118 | 148 | 191 | .21 |
| IgG3 | 37 | 52 | 30 | 30 | 37 | 28 | .48 |
| IgG4 | 24 | 37 | 17 | 5 | 17 | 20 | .20 |
| Missing, n | (0) | (1-2) | (1-2) | (4-9) | (4-12) | (1-4) | |
| Antibody titers (mean) | |||||||
| Streptococcus pneumoniae (% >1.3 g/mL) | 81 | 62 | 58 | 43 | 40 | 73 | .054 |
| Haemophilus influenzae, mg/L | 0.6 | 0.9 | 1.1 | 0.7 | 2.3 | 0.6 | .59 |
| Tetanus, IU/mL | 1.5 | 2.2 | 1.4 | 1.2 | 0.8 | 1.2 | .18 |
| Diphtheria, IU/mL | 0.3 | 0.5 | 0.5 | 0.3 | 0.1 | 0.3 | .49 |
| Missing, n | (0) | (0-2) | (1-2) | (5-10) | (7-10) | (2-4) | |
| Flow cytometry (count of cells/μL, %) | |||||||
| CD3+ (% CD45+) | 1,569, 71 | 1,670, 71 | 1,271, 72 | 1,181, 71 | 983, 73 | 1,118, 71 | .31 |
| CD4+ (% CD45+) | 1,183, 54 | 928, 44 | 915, 52 | 819, 48 | 475, 37 | 612, 39 | <.01 |
| CD8+ (% CD45+) | 333, 15 | 599, 22 | 310, 29 | 317, 20 | 439, 31 | 431, 27 | .85 |
| CD3–CD16+56+ (%CD45+) | 188, 8 | 158, 10 | 269, 15 | 223, 12 | 143, 11 | 252, 22 | .33 |
| CD4+CD45RA+ (%CD4+) | 507, 43 | 473, 50 | 343, 40 | 385, 43 | 139, 27 | 326, 47 | <.01 |
| CD4+CD45RO+ (%CD4+) | 599, 51 | 360, 39 | 416, 49 | 413, 49 | 306, 67 | 265, 48 | .19 |
| CD8+CD45RA+ (%CD8+) | 202, 63 | 416, 64 | 133, 44 | 137, 50 | 246, 52 | 262, 59 | .53 |
| CD8+CD45RO+ (%CD8+) | 111, 30 | 130, 26 | 122, 40 | 109, 42 | 172, 39 | 147, 35 | .8 |
| CD19+ (% CD45+) | 439, 19 | 378, 15 | 230, 12 | 223, 14 | 170, 12 | 57, 4 | <.01 |
| CD19+CD27+ (%CD19+) | 25, 6 | 88, 17 | 36, 16 | 40, 18 | 42, 29 | 21, 14 | .69 |
| CD19+CD27+IgM/IgD– (%CD19+) | 9, 2 | 29, 5 | 13, 6 | 10, 5 | 4,4 | 9, 6 | .13 |
| CD19+CD27+IgM/IgD+ (%CD19+) | 16 | 60 | 6 | 32 | 33 | 15 | .65 |
| Missing, n | 0 | (1) | (1-2) | (0-7) | (0-6) | (2-5) | |
| Severity markers (n, % severe) | |||||||
| <20% CD45RA+ (%CD4+) | 1, 33 | 0 | 0 | 1, 6 | 5, 31 | 0 | .19 |
| Missing (n = 12) | |||||||
| <5% CD27+ (%CD19+) | 1, 33 | 1, 25 | 0 | 3, 18 | 2, 13 | 2, 50 | .45 |
| Missing (n = 16) | |||||||
| <10% CD27+ (%CD19+) | 3, 100 | 1, 25 | 2, 67 | 6, 35 | 7, 44 | 2, 50 | .39 |
| Missing (n = 16) | |||||||
| <2% CD27+IgM/IgD– (%CD19+) | 1, 33 | 2, 50 | 0, 0 | 7, 41 | 10, 63 | 2, 50 | .51 |
| Missing (n = 16) | |||||||
| <70% S pneumoniae (% >1.3 μg/mL) | 1, 33 | 2, 50 | 2, 67 | 14, 88 | 8, 73 | 2, 29 | .049 |
| Missing (n = 18) | |||||||
| <500 IgG (mg/dL) | 0 | 1, 25 | 1, 25 | 9, 53 | 6, 40 | 4, 44 | .67 |
| Missing (n = 10) | |||||||
| T cell function (n, % abnormal) | |||||||
| Anti-CD3 | 0 | 0 | 0 | 0 | 2, 20 | — | 0.67 |
| Missing (n = 41) | |||||||
| PHA | 0 | 0 | 0 | 0 | 2, 17 | — | 0.65 |
| Missing (n = 38) | |||||||
| PWM | 0 | 0 | 0 | 0 | 0 | — | — |
| Missing (n = 39) | |||||||
| Candida | 0 | 0 | 0 | 1, 13 | 1, 10 | — | 1 |
| Missing (n = 40) | |||||||
| Tetanus | 0 | 0 | 0 | 3, 38 | 6, 60 | — | 0.46 |
| Missing (n = 40) |
PHA, Phytohemagglutinin; PWM, Pokeweed mitogen.