Table 2.
Ovarian cancer cluster regions (OCCR) and breast cancer cluster regions (BCCR) in BRCA1 and BRCA2.
| Gene | #Bin | No. of carriers | Putative region | Bin-starting nucleotide | Bin-ending nucleotide | Ratio (OR-breast: OR-ovarian) | P value | FDR P value |
|---|---|---|---|---|---|---|---|---|
| BRCA1 | 1 | 58 | 34 | 335 | 0.81 (0.45–1.47) | 0.49 | 0.63 | |
| 2 | 58 | 397 | 1115 | 0.78 (0.44–1.41) | 0.4126 | 0.6189 | ||
| 3 | 63 | OCCR1 | 1154 | 2111 | 0.29 (0.15–0.57) | 0.0001539 | 0.0012186 | |
| 4 | 58 | 2127 | 3229 | 1.07 (0.61–1.89) | 0.8066 | 0.8066 | ||
| 5 | 62 | 3257 | 3771 | 0.78 (0.44–1.37) | 0.3852 | 0.6189 | ||
| 6 | 59 | 3841 | 4573 | 0.88 (0.48–1.60) | 0.6704 | 0.7542 | ||
| 7 | 58 | 4609 | 5095 | 1.65 (0.92–2.97) | 0.09114 | 0.27342 | ||
| 8 | 59 | 5096 | 5468-1 | 1.46 (0.80–2.66) | 0.2158 | 0.48555 | ||
| 9 | 66 | BCCR1 | 5470 | 5524 | 3.12 (1.65–5.88) | 0.0002708 | 0.0012186 | |
|
| ||||||||
| BRCA2 | 1 | 41 | BCCR2 | 10 | 2176 | 3.47 (1.51–7.96) | 0.002485 | 0.012425 |
| 2 | 41 | 2244 | 4038 | 1.00 (0.47–2.14) | 0.9981 | 0.9981 | ||
| 3 | 48 | 4151 | 5723 | 0.49 (0.23–1.04) | 0.0603 | 0.1005 | ||
| 4 | 41 | OCCR2 | 5745 | 7805 + 1 | 0.38 (0.16–0.86) | 0.01789 | 0.044725 | |
| 5 | 40 | 7835 | 10150 | 1.63 (0.73–3.62) | 0.2281 | 0.285125 | ||
OR: odds ratio; FDR: false discovery rate.