Table 2.

Risk factors for hepatic metastases in patients with r-NENs.

Characteristics	Hepatic metastases		P value	Multivariate analysis
	Yes	No		Odds ratio	95% CI		P value
					Lower	Upper
Age (yr)			<0.0001
<50	45 (26.8%)	1045 (22.9%)		Reference
50-69	93 (55.4%)	3147 (69.1%)		0.712	0.445	1.138	0.156
≥70	30 (17.9%)	363 (8.0%)		0.880	0.460	1.684	0.699
Race			0.002
White	110 (65.5%)	2451 (53.8%)		Reference
Black	33 (19.6%)	1096 (24.1%)		1.325	0.802	2.188	0.272
Other	25 (14.9%)	748 (16.4%)		1.358	0.762	2.419	0.299
Unknown	0 (0.0%)	260 (5.7%)		0.000	0.000		0.994
Gender			0.058
Male	96 (57.1%)	2263 (49.7%)		Reference
Female	72 (42.9%)	2292 (50.3%)		0.729	0.488	1.089	0.123
Grade			<0.0001
G1	26 (15.5%)	2133 (46.8%)		Reference
G2	10 (6.0%)	363 (8.0%)		0.997	0.433	2.298	0.995
G3	62 (36.9%)	66 (1.4%)		6.347	3.286	12.260	≤0.001
G4	34 (20.2%)	31 (0.7%)		6.634	3.036	14.495	≤0.001
Unknown	36 (21.4%)	1962 (43.1%)		1.191	0.690	2.056	0.529
Tumor size			<0.0001
<1 cm	1 (0.6%)	2420 (53.1%)		Reference
1-2 cm	17 (10.1%)	405 (8.9%)		58.514	7.580	451.674	≤0.001
>2 cm	101 (60.1%)	173 (3.8%)		83.963	9.859	715.040	≤0.001
Unknown	49 (29.2%)	1557 (34.2%)		19.874	2.292	172.330	0.007
T stage			<0.0001
T1	12 (7.1%)	2689 (59.0%)		Reference
T2	34 (20.2%)	194 (4.3%)		2.793	1.036	7.526	0.042
T3	49 (29.2%)	65 (1.4%)		4.510	1.673	12.156	0.003
T4	19 (11.3%)	20 (0.4%)		5.933	1.762	19.982	0.004
Tx	54 (32.1%)	1587 (34.8%)		2.635	0.939	7.398	0.066
N stage			<0.0001
N0	55 (32.7%)	4255 (93.4%)		Reference
N1	88 (52.4%)	106 (2.3%)		4.131	2.411	7.079	≤0.001
Nx	25 (14.9%)	194 (4.3%)		6.140	3.390	11.119	≤0.001