Table 4.

Multivariate analysis of OS and CSS in the patients with r-NENs and hepatic metastases.

Characteristics	P value	Overall survival			P value	Cancer-specific survival
		Hazard ratio	95% CI			Hazard ratio	95% CI
			Lower	Upper			Lower	Upper
Age(yr)
<50		Reference				Reference
50-69	0.089	1.482	0.942	2.331	0.169	1.382	0.872	2.189
≥70	0.161	1.537	0.842	2.806	0.357	1.338	0.720	2.484
Race
White		Reference				Reference
Black	0.852	0.955	0.590	1.546	0.835	1.053	0.646	1.717
Other	0.003	0.390	0.211	0.722	0.009	0.435	0.234	0.809
Grade
G1		Reference				Reference
G2	0.361	1.646	0.565	4.796	0.316	1.741	0.588	5.156
G3	≤0.001	6.555	2.885	14.896	≤0.001	6.962	2.992	16.198
G4	0.005	3.416	1.447	8.065	0.008	3.353	1.376	8.169
Unknown	0.027	2.568	1.112	5.930	0.021	2.743	1.163	6.466
T stage
T1		Reference				Reference
T2	0.288	0.599	0.233	1.543	0.296	0.584	0.214	1.599
T3	0.595	0.774	0.301	1.991	0.625	0.779	0.286	2.122
T4	0.592	1.315	0.482	3.586	0.526	1.407	0.490	4.039
Tx	0.425	0.682	0.266	1.746	0.428	0.667	0.245	1.814
N stage
N0		Reference				Reference
N1	0.057	1.526	0.987	2.360	0.088	1.477	0.943	2.315
Nx	0.029	1.942	1.069	3.526	0.027	2.010	1.085	3.726
Surgery of the primary
No surgery		Reference				Reference
Local	0.002	0.224	0.087	0.575	0.002	0.205	0.075	0.564
Radical	0.001	0.292	0.138	0.615	0.002	0.308	0.144	0.659
Chemotherapy
Yes		Reference				Reference
No	0.022	1.812	1.089	3.016	0.032	1.782	1.050	3.024