Table 1.
The most important SNPs detected in the IL-1 family members.
| ILs | SNPs | Chromosome Location | Allele | SNP Class | Type of Disease | References |
|---|---|---|---|---|---|---|
| IL-1α | rs17561 | 2:112779646 (GRCh38), 2:113537223 (GRCh37) | C>A | missense | Increase in BMI among the healthy obese women | [275, 276, 286], (https://www.ncbi.nlm.nih.gov/snp/?term=IL-%CE%B1+rs17561) |
| rs1800587 | 2:112785383 (GRCh38) 2:113542960 (GRCh37) |
G>A / G>C / G>T | Single Nucleotide Variation (SNV) | Alzheimer's disease, chronic periodontitis, increase in BMI among the healthy obese women, and higher expression of IL-1α in transfected pancreatic cell | [276–280, 282], (https://www.ncbi.nlm.nih.gov/snp/?term=rs1800587) | |
| IL-1ß | rs1143634 | 2:112832813 (GRCh38),2:113590390 (GRCh37) | G>A | SNV | The increase of serum IL-1β level, possible association with higher risk of lung cancer especially among smokers, increased risk of CP, a genetic risk factor for periodontitis, some linkages between this SNP and the development of ASD among Turkish (Turkey) children are recognized, and increase in serum levels of IL1β in SLE patients | [291–295, 298, 299](https://www.ncbi.nlm.nih.gov/snp/?term=rs1143634) |
| rs1143627 | 2:112836810 (GRCh38)2:113594387 (GRCh37) | G>A | SNV | carriers of IL-1B rs1143627 genotypes AA had a higher risk of CALs in KD | [302](https://www.ncbi.nlm.nih.gov/snp/?term=rs1143627) | |
| rs16944 | 2:112837290 (GRCh38) 2:113594867 (GRCh37) |
A>G | SNV | This SNP is involved in IL-1β overproduction in inflammation-related conditions, such as bladder, colon, breast, and lung cancer, increasing the risk of keratoconus in Korean patients, associated with cutaneous leishmaniasis caused by Leishmania guyanensis | [303, 304, 307](https://www.ncbi.nlm.nih.gov/snp/?term=rs16944) | |
| IL-1RN | rs419598 | 2:113129630 (GRCh38)2:113887207 (GRCh37) | T>C | SNV | might be associated with a reduced susceptibility to GAgP and GCP in populations of European descent, increasing more severe rOA, | [312, 317](https://www.ncbi.nlm.nih.gov/snp/?term=rs419598) |
| rs315952 | 2:113132727 (GRCh38)2:113890304 (GRCh37) | T>A,C | SNV | increasing more severe rOA, | [317](https://www.ncbi.nlm.nih.gov/snp/?term=rs315952) | |
| rs9005 | 2:113133835 (GRCh38)2:113891412 (GRCh37) | G>A | SNV | increasing more severe rOA, | [317](https://www.ncbi.nlm.nih.gov/snp/?term=rs9005) | |
| IL-18 | More investigations are needed | |||||
| IL-33 | More investigations are needed | |||||