Table 2.

Validated ferroptosis regulators in the UC model.

Gene/axis/compound	Mechanism	Function
Ferrostatin-1 [19, 92]	Downregulation of PTGS2 levels, MDA levels, and iron content	Inhibition
Furin [46]	Activation of Nrf2 and upregulation of Gpx4 expression	Inhibition
MELK [48]	Inhibited ferritin formation in intestinal tissues	Inhibition
Lip-1 [19]	Blocking Nrf2/HO-1 and reducing the levels of COX2, ACSL4, FTH1	Inhibition
Deferprone [19]	Blocking Nrf2/HO-1 and reducing the levels of COX2, ACSL4, FTH1	Inhibition
NF-κBp65 [16]	Inhibition of endoplasmic reticulum stress	Inhibition
Curculigoside [47]	Induction of GPX4	Inhibition
Fer-1 [16]	Reduces MDA, iron, and FTH levels	Inhibition
Astragalus polysaccharide [49]	Inhibiting NRF2/HO-1 pathway	Inhibition
RSL3 [16]	Accumulation of ROS	Induction