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. 2022 Mar;11(3):385–395. doi: 10.21037/tp-22-33

Figure 5.

Figure 5

The impaired KEGG pathway annotations at level 3, as determined by Tax4Fun. The functional profile in TOF patients showed a greater abundance of pathways involved in (A) NF-κB signaling pathway, (B) oxidative phosphorylation, (C) cytokine-cytokine receptor interaction, and (D) VEGF signaling pathway. TOF patients showed a fewer abundance of pathways involved in (E) ribosome biogenesis in eukaryotes and (F) glutathione metabolism. *, P<0.05; **, P<0.01. KEGG, Kyoto Encyclopedia of Genes and Genomes; TOF, Tetralogy of Fallot; NF-κB, nuclear factor-kappa B; VEGF, vascular endothelial growth factor.