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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Lancet Respir Med. 2022 Jan 10;10(4):367–377. doi: 10.1016/S2213-2600(21)00461-6

Table 3. Mortality at day 90 in PEEP-groups stratified by ARDS Subphenotypes in LUNG SAFE (n=2813).

ARDS Subphenotypes were assigned by a custom clinical classifier (“LUNG SAFE”) model using a probability cutoff of 0·4. PEEP subgroups were defined as “high PEEP” (n=992; median PEEP 11 cm H2O [10 – 12]) and “low PEEP” (n=943; median 5 cm H2O [5 – 6]) subgroups based on the mean PEEP over the first three days.

Subphenotype Mortality in Low PEEP group Mortality in High PEEP group P value
Hyperinflammatory 62% (127/205) 54% (169/313) 0·041
Hypoinflammatory 32% (233/734) 34% (231/675)

P-value is for the interaction term of PEEP subgroups and ARDS subphenotypes with mortality as the dependent variable and was derived using the Wald test. Abbreviations: Positive End Expiratory Pressure (PEEP).