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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Horm Behav. 2022 Jan 29;140:105124. doi: 10.1016/j.yhbeh.2022.105124

Fig. 2. Ovariectomy induces an APOE4-like anxiety phenotype in E3FAD females.

Fig. 2.

(A) Track plots illustrate representative patterns of movement in ovariectomized EFADs in the open field. (B) E3FAD females spent significantly more time in the center than E4FAD females (&p < 0.05, main effect of genotype), and intact E3FADs spent significantly more time in the center than OVXed EFADs ($$$p < 0.0001, main effect of OVX). Intact E3FADs spent significantly more time in the center relative to every other group (^^p < 0.01, significant interaction; **p < 0.01 vs OVXed E3FADs, ***p < 0.001 vs intact and OVXed E4FADs). (C,D) Distance traveled and average speed did not differ among female EFADs regardless of genotype or gonadal status.