Figure 3.
Pharmacodynamic studies measuring PARP trapping and DNA damage and repair in samples from patients with Day 1 (pre-treatment) and Day 5 and 8 peripheral blood blasts. A. Proximity ligation assay (PLA) measuring PARP1 trapping at γH2AX foci. B. PLA data in patients who achieved CRi. C. γH2AX foci. D. γH2AX foci in patients who achieved CRi. E. Homologous recombination (HR) activity. CRi = Complete remission with incomplete count recovery; HI = Hematologic improvement; NR = No response; NE = Not evaluable.