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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: J Physiol. 2022 Feb 1;600(7):1651–1666. doi: 10.1113/JP281873

Figure 10. Arterial stretch activates TRPV1 in a PLC/PKC dependent manner.

Figure 10.

A and B, Changes in the diameter of pressurized (80 mm Hg, 34–35°C) skeletal muscle arterioles from WT and TRPV1-null mice treated with the PLC inhibitor, U73122 (10 μM, n = 4), the inactive analog, U73343 (10 μM, n = 4), nifedipine (5 μM, n = 3) and the PKC inhibitor, GF 109203X (n = 4, nested one-way ANOVA), C, Proposed signaling cascade for the generation of TRPV1-dependent myogenic tone in skeletal muscle arterioles.