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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: J Physiol. 2022 Feb 1;600(7):1651–1666. doi: 10.1113/JP281873

Figure 2. TRPV1 antagonists dilate skeletal muscle arterioles in vivo.

Figure 2.

A, Intravital imaging show that BCTC (1 μM) dilates in vivo radial branch arterioles (red arrows) without affecting arterioles in TRPV1- null mice or veins (green arrows). B, Mean arteriole dilation evoked by BCTC in WT and TRPV1-null mice (n = 5 mice, 5 arteries) and maximal dilation with zero Ca2+/EGTA (unpaired t-test). C and D, Concentration-dependent dilation by BCTC normalized to zero Ca2+/EGTA (n = 4 arteries, 4 mice, one-way ANOVA Tukey’s Multi. comp.). E BCTC-evoked dilation in small (~25 μm, n = 8 arteries, 5 mice) and medium (~60 μm, n = 5 arteries, 4 mice) diameter arteries (unpaired t-test). F, Resting tone in small (n = 5 arteries, 4 mice) and medium (n = 4 arteries, 4 mice) diameter arteries (unpaired t-test).