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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: J Physiol. 2022 Feb 1;600(7):1651–1666. doi: 10.1113/JP281873

Figure 8. TRPV1 is critical for reactive vasodilation.

Figure 8.

A-C, Arterial dilation following 40 s constriction evoked by KCl (40 mM) or blue light (TRPV1-ChR2 mice) and the reemergence of tone. BCTC and disruption of the TRPV1 gene inhibits the magnitude of the dilation and rate of recovery of tone (WT, n = 5 mice, 5 arteries; WT+BCTC, n = 5 mice, 5 arteries; TRPV1-null, n = 4 mice, 4 arteries; TRPV1-ChR2, n = 5 mice, 5 arteries, unpaired t-test). D-F, Dilation of medium- (~60 μm) and small (~25 μm) diameter arteries in response to 4 s blue light (TRPV1-ChR2 mice) or 6 s application of 40 mM KCl (WT, 60 μm, 3 mice, 3 arteries; 25 μm, 5 mice, 5 arteries; TRPV1-null, 60 and 25 μm, n = 4 mice, 4 arteries; TRPV1-ChR2, n = 5 mice, 5 arteries, unpaired t-test).