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. 2022 Jan 29;388(1):181–194. doi: 10.1007/s00441-022-03587-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Esomeprazole inhibits autophagy in HTR-8/Svneo cells by suppressing the SIRT1/AMPKα pathway. (a–c″) Immunofluorescence staining of p-AMPKα in control or esomeprazole-treated HTR-8/Svneo. (d) Western blot analysis of the expression levels of p-AMPKα, AMPKα, PPARγ, SIRT1, mTOR, and p-mTOR in control or esomeprazole-treated HTR-8/Svneo. (e–e⁗) Plots showing the quantification of HIF1α, PPARγ, p-AMPKα/AMPKα, and p-mTOR/ mTOR. All data are representative of three independent experiments: *P < 0.05, **P < 0.01