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. 2021 Dec 10;45(2):1721–1729. doi: 10.1007/s10143-021-01711-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Workflow for the exploration of histopathological based neurosurgical decision-making. a Coronal schematic of possible neurosurgical approach for brain tumors using intraoperative SRH imaging for detection of the tumor borders. b Use of a frameless image-guided stereotactic biopsy system through a burr hole at the center of the planned craniotomy. Yellow arrowhead symbolizes samples dedicated to conventional neuropathological diagnostic, and white arrowhead symbolizes intraoperative SRH. c Craniotomy with potential brain shift and loss of navigation accuracy over time. d Sampling of resection borders to guide resection or for assessment of final resection margins. Program used to create figure, Adobe Illustrator CS 6 and BioRender.com (2021)