Table 2.
Top 100 cited articles on ependymoma by average citations per year
| Rank by total citations | Rank by average citations per year | Title | Authors (first and last) | Journal title | Publication year | Total citations | Average citations per year | Country | Type of study |
|---|---|---|---|---|---|---|---|---|---|
| 3 | 1 | Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups | Pajtler KW, Pfister SM | Cancer Cell | 2015 | 321 | 53.5 | Germany | Basic science |
| 5 | 2 | C11orf95-RELA fusions drive oncogenic Nf-kappa B signalling in ependymoma | Parker M, Gilbertson RJ | Nature | 2014 | 272 | 38.86 | USA | Basic science |
| 1 | 3 | Radial glia cells are candidate stem cells of ependymoma | Taylor MD, Gilbertson RJ | Cancer Cell | 2005 | 551 | 34.44 | USA | Basic science |
| 7 | 4 | Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma | Witt H, Pfister SM | Cancer Cell | 2011 | 244 | 24.4 | Germany | Basic science |
| 50 | 5 | The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants | Pajtler KW, Taylor MD | Acta Neuropathologica | 2017 | 89 | 22.25 | Germany | Review |
| 6 | 6 | Conformal radiotherapy after surgery for paediatric ependymoma: a prospective study | Merchant TE, Sanford RA | Lancet Oncology | 2009 | 258 | 21.5 | USA | Clinical |
| 9 | 7 | Cross-species genomics matches driver mutations and cell compartments to model ependymoma | Johnson RA, Gilbertson RJ | Nature | 2010 | 219 | 19.91 | USA | Basic science |
| 2 | 8 | Intramedullary ependymoma of the spinal cord | Mccormick PC, Stein BM | Journal of Neurosurgery | 1990 | 453 | 14.61 | USA | Clinical |
| 82 | 9 | Clinical evidence of variable proton biological effectiveness in pediatric patients treated for ependymoma | Peeler CR, Grosshans DR | Radiotherapy and Oncology | 2016 | 65 | 13 | USA | Clinical |
| 83 | 10 | Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: a retrospective multicohort analysis | Ramaswamy V, Taylor MD | Journal of Clinical Oncology | 2016 | 65 | 13 | Canada | Clinical |
| 30 | 11 | Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts | Ellison DW, Grundy RG | Journal of Negative Results in Biomedicine | 2011 | 123 | 12.3 | USA | Clinical |
| 11 | 12 | Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma | Merchant TE, Sanford RA | Journal of Clinical Oncology | 2004 | 201 | 11.82 | USA | Clinical |
| 35 | 13 | Molecular staging of intracranial ependymoma in children and adults | Korshunov A, Pfister SM | Journal of Clinical Oncology | 2010 | 119 | 10.82 | Germany | Basic science |
| 14 | 14 | Identification of tumor-specific molecular signatures in intracranial ependymoma and association with clinical characteristics | Modena P, Sozzi G | Journal of Clinical Oncology | 2006 | 160 | 10.67 | Italy | Basic science |
| 15 | 15 | Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma | Mendrzyk F, Lichter P | Clinical Cancer Research | 2006 | 156 | 10.4 | Germany | Basic science |
| 23 | 16 | Primary postoperative chemotherapy without radiotherapy for intracranial ependymoma in children: the UKCCSG/SIOP prospective study | Grundy RG, Machin D | Lancet Oncology | 2007 | 139 | 9.93 | UK | Clinical |
| 27 | 17 | Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons | Macdonald SM, Yock T | International Journal of Radiation Oncology Biology Physics | 2008 | 126 | 9.69 | USA | Clinical |
| 69 | 18 | Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients | Macdonald SM, Yock TI | Neuro-Oncology | 2013 | 76 | 9.5 | USA | Clinical |
| 38 | 19 | Incidence patterns for ependymoma: a surveillance, epidemiology, and end results study clinical article | Mcguire CS, Fisher PG | Journal of Neurosurgery | 2009 | 112 | 9.33 | USA | Clinical |
| 63 | 20 | A prognostic gene expression signature in infratentorial ependymoma | Wani K, Aldape K | Acta Neuropathologica | 2012 | 78 | 8.67 | USA | Basic science |
| 13 | 21 | Postoperative chemotherapy without irradiation for ependymoma in children under 5 years of age: a multicenter trial of the French society of pediatric oncology | Grill J, Kalifa C | Journal of Clinical Oncology | 2001 | 173 | 8.65 | France | Clinical |
| 42 | 22 | Pediatric ependymoma: biological perspectives | Kilday JP, Grundy R | Molecular Cancer Research | 2009 | 101 | 8.42 | UK | Review |
| 100 | 23 | Clinical, radiological, histological and molecular characteristics of paediatric epithelioid glioblastoma | Broniscer A, Ellison DW | Neuropathology and Applied Neurobiology | 2014 | 58 | 8.29 | USA | Clinical |
| 57 | 24 | Identification of microRNAs as potential prognostic markers in ependymoma | Costa FF Soares MB | Plos One | 2011 | 80 | 8 | USA | Basic science |
| 10 | 25 | Natural simian-virus-40 strains are present in human choroid-plexus and ependymoma tumors | Lednicky JA, Butel JS | Virology | 1995 | 206 | 7.92 | USA | Basic science |
| 32 | 26 | Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma | Wang M, Burger PC | Journal of Neuropathology and Experimental Neurology | 2005 | 121 | 7.56 | USA | Clinical |
| 46 | 27 | A retrospective study of surgery and reirradiation for recurrent ependymoma | Merchant TE, Sanford RA | International Journal of Radiation Oncology Biology Physics | 2008 | 96 | 7.38 | USA | Clinical |
| 74 | 28 | An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma | Atkinson JM, Gilbertson RJ | Cancer Cell | 2011 | 71 | 7.1 | USA | Basic science |
| 16 | 29 | Molecular genetic analysis of ependymal tumors: Nf2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas | Ebert C, Von Deimling A | American Journal of Pathology | 1999 | 154 | 7 | USA | Basic science |
| 88 | 30 | Survival benefit for pediatric patients with recurrent ependymoma treated with reirradiation | Bouffet E, Tabori U | International Journal of Radiation Oncology Biology Physics | 2012 | 62 | 6.89 | Canada | Clinical |
| 55 | 31 | Both location and age predict survival in ependymoma: a seer study | Mcguire CS, Fisher PG | Pediatric Blood & Cancer | 2009 | 81 | 6.75 | USA | Clinical |
| 26 | 32 | Spinal cord ependymoma: radical surgical resection and outcome | Hanbali F, Gokaslan ZL | Neurosurgery | 2002 | 127 | 6.68 | USA | Clinical |
| 4 | 33 | Ependymoma: follow-up-study of 101 cases | Mork SJ, Loken AC | Cancer | 1977 | 290 | 6.59 | Norway | Clinical |
| 18 | 34 | Expression of vascular endothelial growth factor and its receptors in the anaplastic progression of astrocytoma, oligodendroglioma, and ependymoma | Chan AS, Chung LP | American Journal of Surgical Pathology | 1998 | 151 | 6.57 | Hong Kong | Basic science |
| 31 | 35 | Erbb receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease | Gilbertson RJ Ellison DW | Clinical Cancer Research | 2002 | 123 | 6.47 | USA | Basic science |
| 49 | 36 | Ependymoma | Reni M, Vecht C | Critical Reviews in Oncology Hematology | 2007 | 90 | 6.43 | Italy | Review |
| 54 | 37 | Predicting change in academic abilities after conformal radiation therapy for localized ependymoma | Conklin HM, Merchant TE | Journal of Clinical Oncology | 2008 | 83 | 6.38 | USA | Clinical |
| 8 | 38 | Myxopapillary ependymoma: a clinicopathologic and immunocytochemical study of 77 cases | Sonneland PR, Onofrio BM | Cancer | 1985 | 226 | 6.28 | USA | Clinical |
| 58 | 39 | Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective | De Bont JM, Pieters R | Neuro-Oncology | 2008 | 80 | 6.15 | Netherlands | Review |
| 12 | 40 | The prognostic-significance of postoperative residual tumor in ependymoma | Healey EA, Tarbell NJ | Neurosurgery | 1991 | 184 | 6.13 | USA | Clinical |
| 21 | 41 | Analyses of prognostic factors in a retrospective review of 92 children with ependymoma: Italian Pediatric Neuro-oncology Group | Perilongo G, Madon E | Medical and Pediatric Oncology | 1997 | 144 | 6 | Italy | Clinical |
| 64 | 42 | Multifactorial analysis of predictors of outcome in pediatric intracranial ependymoma | Ridley L, Grundy RG | Neuro-Oncology | 2008 | 78 | 6 | UK | Clinical |
| 84 | 43 | Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial | Grundy RG, Machin D | European Journal of Cancer | 2010 | 65 | 5.91 | UK | Clinical |
| 17 | 44 | Treatment of intracranial ependymomas of children: review of a 15-year experience | Rousseau P, Rey A | International Journal of Radiation Oncology Biology Physics | 1994 | 154 | 5.7 | France | Clinical |
| 36 | 45 | Combined postoperative irradiation and chemotherapy for anaplastic ependymomas in childhood: results of the German prospective trials hit 88/89 and hit 91 | Timmermann B Bamberg M | International Journal of Radiation Oncology Biology Physics | 2000 | 118 | 5.62 | Germany | Clinical |
| 33 | 46 | A multi-institutional retrospective study of intracranial ependymoma in children: identification of risk factors | Horn B, Russo C | Journal of Pediatric Hematology Oncology | 1999 | 121 | 5.5 | USA | Clinical |
| 28 | 47 | Ependymoma: results, prognostic factors and treatment recommendations | Mclaughlin MP, Million RR | International Journal of Radiation Oncology Biology Physics | 1998 | 126 | 5.48 | USA | Clinical |
| 59 | 48 | Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at MD Anderson Cancer Center | Akyurek S, Woo SY | Journal of Neuro-Oncology | 2006 | 80 | 5.33 | USA | Clinical |
| 78 | 49 | Differential expression and prognostic significance of sox genes in pediatric medulloblastoma and ependymoma identified by microarray analysis | De Bont JM, Pieters R | Neuro-Oncology | 2008 | 69 | 5.31 | Netherlands | Basic science |
| 70 | 50 | Human telomere reverse transcriptase expression predicts progression and survival in pediatric intracranial ependymoma | Tabori U, Hawkins C | Journal of Clinical Oncology | 2006 | 76 | 5.07 | Canada | Clinical |
| 44 | 51 | Chromosomal abnormalities subdivide ependymal tumors into clinically relevant groups | Hirose Y, Feuerstein BG | American Journal of Pathology | 2001 | 98 | 4.9 | USA | Basic science |
| 65 | 52 | Radiation dosimetry predicts iq after conformal radiation therapy in pediatric patients with localized ependymoma | Merchant TE, Mulhern RK | International Journal of Radiation Oncology Biology Physics | 2005 | 78 | 4.88 | USA | Clinical |
| 66 | 53 | Ependymoma: new therapeutic approaches including radiation and chemotherapy | Merchant TE, Fouladi M | Journal of Neuro-Oncology | 2005 | 78 | 4.88 | USA | Clinical |
| 80 | 54 | Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival | Lukashova-Von Zangen I, Roggendorf W | Acta Neuropathologica | 2007 | 66 | 4.71 | Germany | Basic science |
| 95 | 55 | Central nervous system tumors with ependymal features: a broadened spectrum of primarily ependymal differentiation? | Lehman NL | Journal of Neuropathology And Experimental Neurology | 2008 | 59 | 4.54 | USA | Review |
| 89 | 56 | Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue | Zacharoulis S, Finlay J | Pediatric Blood & Cancer | 2007 | 62 | 4.43 | USA | Clinical |
| 25 | 57 | Intracranial ependymoma: long-term results of a policy of surgery and radiotherapy | Vanuytsel LJ, Brada M | International Journal of Radiation Oncology Biology Physics | 1992 | 128 | 4.41 | UK | Clinical |
| 77 | 58 | The high incidence of tumor dissemination in myxopapillary ependymoma in pediatric patients: report of five cases and review of the literature | Fassett DR, Kestle JRW | Journal of Neurosurgery | 2005 | 70 | 4.38 | USA | Clinical |
| 39 | 59 | Adjuvant chemotherapy of childhood posterior fossa ependymoma: cranio-spinal irradiation with or without adjuvant CCNU, vincristine, and prednisone: a children’s cancer group study | Evans AE, Finlay JL | Medical and Pediatric Oncology | 1996 | 106 | 4.24 | USA | Clinical |
| 45 | 60 | Adjuvant chemotherapy for the treatment of intracranial ependymoma of childhood | Needle MN, Phillips PC | Cancer | 1997 | 97 | 4.04 | USA | Clinical |
| 34 | 61 | Identification of a germ-line mutation in the p53 gene in a patient with an intracranial ependymoma | Metzger AK, Cogen PH | Proceedings of The National Academy of Sciences of the United States of America | 1991 | 120 | 4 | USA | Clinical |
| 79 | 62 | A multicenter study of the prognosis and treatment of adult brain ependymal tumors | Reni M, Villa E | Cancer | 2004 | 68 | 4 | Italy | Clinical |
| 19 | 63 | Improved survival in cases of intracranial ependymoma after radiation-therapy: late report and recommendations | Salazar OM, Aygun C | Journal of Neurosurgery | 1983 | 150 | 3.95 | USA | Clinical |
| 81 | 64 | Ki-67 immunolabeling index is an accurate predictor of outcome in patients with intracranial ependymoma | Wolfsberger S, Hainfellner J | American Journal of Surgical Pathology | 2004 | 66 | 3.88 | Austria | Clinical |
| 37 | 65 | Histologic prognostic factors in ependymoma | Schiffer D, Tribolo A | Childs Nervous System | 1991 | 116 | 3.87 | Italy | Clinical |
| 73 | 66 | Ependymoma in childhood: prognostic factors, extent of surgery, and adjuvant therapy | van Veelen-Vincent, ML, Renier D | Journal of Neurosurgery | 2002 | 72 | 3.79 | Netherlands | Clinical |
| 75 | 67 | Influence of tumor grade on time to progression after irradiation for localized ependymoma in children | Merchant TE, Kun LE | International Journal of Radiation Oncology Biology Physics | 2002 | 71 | 3.74 | USA | Clinical |
| 76 | 68 | Preliminary results from a phase II trial of conformal radiation therapy for pediatric patients with localized low-grade astrocytoma and ependymoma | Merchant TE, Kun LE | International Journal of Radiation Oncology Biology Physics | 2002 | 71 | 3.74 | USA | Clinical |
| 29 | 69 | Postoperative radiotherapy of intracranial ependymoma in pediatric and adult patients | Shaw EG, Earle JD | International Journal of Radiation Oncology Biology Physics | 1987 | 126 | 3.71 | USA | Clinical |
| 90 | 70 | Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma: final results of the first prospective AIEOP (Associazione Italiana di Ematologia-Oncologia Pediatrica) study | Massimino M, Madon E | International Journal of Radiation Oncology Biology Physics | 2004 | 62 | 3.65 | Italy | Clinical |
| 52 | 71 | Anaplastic ependymoma: treatment of pediatric patients with or without craniospinal radiation therapy | Merchant TE, Leibel SA | Journal of Neurosurgery | 1997 | 85 | 3.54 | USA | Clinical |
| 56 | 72 | Treatment of intracranial ependymoma by surgery alone | Hukin J, Allen J | Pediatric Neurosurgery | 1998 | 81 | 3.52 | USA | Clinical |
| 40 | 73 | Postoperative radiotherapy in the management of spinal-cord ependymoma | Whitaker SJ, Brada M | Journal of Neurosurgery | 1991 | 105 | 3.5 | UK | Clinical |
| 24 | 74 | Differential-diagnosis of chordoma, chondroid, and ependymal tumors as aided by anti-intermediate filament antibodies | Miettinen M, Virtanen I | American Journal of Pathology | 1983 | 129 | 3.39 | Finland | Clinical |
| 22 | 75 | Symptomatic subependymoma: report of 21 cases with review of literature | Scheithauer BW | Journal of Neurosurgery | 1978 | 141 | 3.28 | USA | Clinical |
| 91 | 76 | Postoperative radiotherapy for intracranial ependymoma: analysis of prognostic factors and patterns of failure | Oya N, Hiraoka M | Journal of Neuro-Oncology | 2002 | 62 | 3.26 | Japan | Clinical |
| 96 | 77 | Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma | Port JD, Pomper MG | American Journal of Neuroradiology | 2002 | 59 | 3.11 | USA | Clinical |
| 85 | 78 | Chromosome arm 6q loss is the most common recurrent autosomal alteration detected in primary pediatric ependymoma | Reardon DA, Look AT | Genes Chromosomes & Cancer | 1999 | 65 | 2.95 | USA | Basic science |
| 97 | 79 | Stereotactic radiosurgery for recurrent ependymoma | Stafford SL, Schomberg PJ | Cancer | 2000 | 59 | 2.81 | USA | Clinical |
| 98 | 80 | Pediatric low-grade and ependymal spinal cord tumors | Merchant TE, Kun LE | Pediatric Neurosurgery | 2000 | 59 | 2.81 | USA | Clinical |
| 67 | 81 | Intracranial ependymoma long-term outcome, patterns of failure | Kovalic JJ, Roth KA | Journal of Neuro-Oncology | 1993 | 78 | 2.79 | USA | Clinical |
| 41 | 82 | Subcutaneous sacrococcygeal myxopapillary ependymoma: a clinicopathologic study of 32 cases | Helwig EB, Stern JB | American Journal of Clinical Pathology | 1984 | 102 | 2.76 | USA | Clinical |
| 93 | 83 | Clinicopathologic study of 61 patients with ependymoma including mib-1 immunohistochemistry | Prayson RA | Annals of Diagnostic Pathology | 1999 | 60 | 2.73 | USA | Clinical |
| 60 | 84 | Ependymoma: internal correlations among pathological signs: the anaplastic variant | Schiffer D, Vigliani MC | Neurosurgery | 1991 | 80 | 2.67 | Italy | Clinical |
| 62 | 85 | The role of prophylactic spinal irradiation in localized intracranial ependymoma | Vanuytsel L, Brada M | International Journal of Radiation Oncology Biology Physics | 1991 | 79 | 2.63 | UK | Clinical |
| 94 | 86 | Survival following intensive chemotherapy with bone marrow reconstitution for children with recurrent intracranial ependymoma: a report of the children's cancer group | Mason WP, Finlay JL | Journal of Neuro-Oncology | 1998 | 60 | 2.61 | USA | Clinical |
| 53 | 87 | Ependymal and choroid-plexus tumors: cytokeratin and GFAP expression | Mannoji H, Becker LE | Cancer | 1988 | 84 | 2.55 | Canada | Clinical |
| 68 | 88 | Intracranial ependymoma and subependymoma: MR manifestations | Spoto GP, Solomon M | American Journal of Neuroradiology | 1990 | 78 | 2.52 | USA | Clinical |
| 72 | 89 | Intracranial ependymoma in children: analysis of prognostic factors | Chiu JK, Shallenberger R | Journal of Neuro-Oncology | 1992 | 73 | 2.52 | USA | Clinical |
| 86 | 90 | MR characteristics of histopathologic subtypes of spinal ependymoma | Kahan H, Bruce JH | American Journal of Neuroradiology | 1996 | 63 | 2.52 | USA | Clinical |
| 99 | 91 | Tanycytic ependymoma | Langford LA, Barre GM | Ultrastructural Pathology | 1997 | 59 | 2.46 | USA | Clinical |
| 92 | 92 | A high-dose busulfan-thiotepa combination followed by autologous bone marrow transplantation in childhood recurrent ependymoma: a phase-II study | Grill J, Hartmann O | Pediatric Neurosurgery | 1996 | 61 | 2.44 | France | Clinical |
| 43 | 93 | Extra-spinal ependymomas: report of 3 cases | Morantz RA, Masterson BJ | Journal of Neurosurgery | 1979 | 99 | 2.36 | USA | Clinical |
| 20 | 94 | A metastasizing ependymoma of the cauda equina | Weiss, L | Cancer | 1955 | 148 | 2.24 | USA | Clinical |
| 48 | 95 | Delayed distant metastasis from a subcutaneous sacrococcygeal ependymoma: case report, with tissue-culture, ultrastructural observations and review of literature | Wolff M, Duby MM | Cancer | 1972 | 93 | 1.9 | USA | Review |
| 47 | 96 | Secretory ependymoma of filum terminale | Miller CA Torack RA | Acta Neuropathologica | 1970 | 95 | 1.86 | USA | Clinical |
| 51 | 97 | Is subependymoma (subependymal glomerate astrocytoma) an astrocytoma or ependymoma: comparative ultrastructural and tissue-culture study | Fu YS, Young HF | Cancer | 1974 | 86 | 1.83 | USA | Clinical |
| 87 | 98 | Melanin as a component of cerebral gliomas: melanotic cerebral ependymoma | Mccloskey JJ, Blacker HM | Cancer | 1976 | 63 | 1.4 | USA | Clinical |
| 61 | 99 | Ependymoma of the brain: pathologic aspects | Svien HJ, Craig WM | Neurology | 1953 | 80 | 1.18 | USA | Review |
| 71 | 100 | A study of tumors arising from ependymal cells | Bailey P | Archives of Neurology And Psychiatry | 1924 | 75 | 0.77 | USA | Clinical |