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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: J Immunol. 2022 Mar 18;208(7):1595–1615. doi: 10.4049/jimmunol.2100439

FIGURE 7. IL22 participates in host response to Ureaplasma parvum in the placenta, fetal membranes, fetal lung, and fetal intestine in mice.

FIGURE 7.

(A) Expression of Il22, Il10rb, Il22ra1, and Il22ra2 in the fetal membranes of mice intra-amniotically injected with Ureaplasma parvum (n = 8) or SP4 broth (n = 8). (B) Expression of Il22, Il10rb, Il22ra1, and Il22ra2 in the placentas of mice intra-amniotically injected with Ureaplasma parvum (n = 8) or SP4 broth (n = 8). Heatmap representations showing inflammatory gene expression in the (C) lung and (D) intestine of fetuses of mice intra-amniotically injected with Ureaplasma parvum (n = 8) or SP4 broth (n = 8). Stars indicate significant differentially expressed genes. (E) Expression of Nfkb2, Il1a, Il1b, Il6, Tnf, Il12b (Il12p40), Ccl2, Ccl3, Cxcl1, Cxcl5, Cxcl10, Il10rb, Il23a, Il27, and Lrg1 in the lung of fetuses of mice intra-amniotically injected with Ureaplasma parvum (n = 8) or SP4 broth (n = 8). (F) Expression of Nfkb2, Il22ra1, and Lrg1 in the intestine of fetuses of mice intra-amniotically injected with Ureaplasma parvum (n = 8) or SP4 broth (n = 8). P-values were determined using Mann-Whitney U-tests.