Table I.
Demographic and clinical characteristics of the study population for immunophenotyping of cellular sources of IL-22
| Term not in labor (n=11) | Term in labor (n=30) | Preterm not in labor (n=11) | Preterm in labor (n=26) | p-value | |
|---|---|---|---|---|---|
| Maternal age (years; median [IQR])a | 26 (23–31) | 24 (20.3–25.8) | 31 (27.5–33) | 26 (22.3–28.8) | 0.004 |
| Body mass index (kg/m2; median [IQR])a | 35.1 (29.2–39) | 25.6 (23–31.2) | 34.7 (29.1–35.8) | 31.1 (25.9–40.4)c | 0.02 |
| Primiparityb | 0% (0/11) | 6.7% (2/30) | 0% (0/11) | 23.1% (6/26) | 0.09 |
| Race/ethnicityb | 0.4 | ||||
| African-American | 81.8% (9/11) | 90% (27/30) | 90.9% (10/11) | 76.9% (20/26) | |
| White | 18.2% (2/11) | 3.3% (1/30) | 9.1% (1/11) | 19.2% (5/26) | |
| Other | 0% (0/11) | 6.7% (2/30) | 0% (0/11) | 3.8% (1/26) | |
| Gestational age at delivery (weeks; median [IQR])a | 39.1 (39–39.3) | 39.2 (38.6–40.3) | 33.4 (31–36.4) | 34.6 (33.7–35.9) | <0.001 |
| Birthweight (grams; median [IQR])a | 3370 (3125–3705) | 3188 (2839–3319) | 1730 (1383–2508) | 2233 (1809–2440) | <0.001 |
| Acute maternal inflammatory responseb | |||||
| Stage 1 (Early acute subchorionitis or chorionitis) | 9.1% (1/11) | 33.3% (10/30) | 0% (0/11) | 15.4% (4/26) | 0.07 |
| Stage 2 (Acute chorioamnionitis) | 0% (0/11) | 23.3% (7/30) | 0% (0/11) | 15.4% (4/26) | 0.14 |
| Stage 3 (Necrotizing chorioamnionitis) | 0% (0/11) | 0% (0/30) | 0% (0/11) | 0% (0/26) | 1 |
| Acute fetal inflammatory responseb | |||||
| Stage 1 (Chorionic vasculitis or umbilical phlebitis) | 0% (0/11) | 23.3% (7/30) | 0% (0/11) | 3.8% (1/26) | 0.06 |
| Stage 2 (Umbilical arteritis) | 0% (0/11) | 6.7% (2/30) | 0% (0/11) | 15.4% (4/26) | 0.4 |
| Stage 3 (Necrotizing funisitis) | 0% (0/11) | 0% (0/30) | 0% (0/11) | 0% (0/26) | 1 |
Data are given as median (interquartile range, IQR) and percentage (n/N).
a
Kruskal-Wallis test,
b
Fisher’s exact test,
c
Three missing data.