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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Neurobiol Aging. 2021 Dec 7;112:39–54. doi: 10.1016/j.neurobiolaging.2021.11.006

Table 1:

Locus coeruleus masks included in comparisons

Publication MRI acquisition Sample Locus coeruleus segmentaion Mask source Mask version
Betts et al., 2017 3 T; FLASH N = 82; YA; OA Manual https://doi.org/10.1016/j.neuroimage.2017.09.042 --
Dahl et al., 2019 3 T; TSE N = 294; YA; OA Semi-automatic https://www.mpib-berlin.mpg.de/LC-Map --
Keren et al., 2009 3 T; TSE N = 44; YA–OA Semi-automatic http://www.eckertlab.org/LC 1 SD
Liu et al., 2019 3 T; MT N = 605; YA–OA Manual https://osf.io/r2bwk --
Tona et al. 2017 3 T; TSE N = 17; YA Manual http://www.nitrc.org/projects/prob_lc_3t 1
Ye et al., 2021 7 T; MT N = 53; OA Semi-automatic https://www.nitrc.org/projects/lc_7t_prob 5% prob.2

Note:

1

The masks provided by Tona and colleagues were averaged across scan sessions and segmentations.

2

The mask by Ye and colleagues was linearly and non-linearly co-registered from MNI-ICBM 152 non-linear 2009b to MNI-ICBM 152 linear space (0.5 mm resolution) using Advanced Normalization Tools (antsRegistration). MNI-ICBM 152 linear was chosen as target space as all but one masks share this space. For co-registration, the standard brains of the respective spaces were aligned and the transformations were applied to the mask file with a nearest neighbor interpolation. The transformations from MNI 2009b non-lin ⇔ MNI linear are shared via osf.io/sf2ky/;

T, Tesla; FLASH, Fast Long Angle Shot; TSE, Turbo Spin Echo; MT, Magnetization Transfer; YA, Younger Adults; OA, Older Adults; YA–OA, lifespan sample including younger, middle-aged and older adults; SD, standard deviation; prob., probability.