Table 1:
Publication | MRI acquisition | Sample | Locus coeruleus segmentaion | Mask source | Mask version |
---|---|---|---|---|---|
Betts et al., 2017 | 3 T; FLASH | N = 82; YA; OA | Manual | https://doi.org/10.1016/j.neuroimage.2017.09.042 | -- |
Dahl et al., 2019 | 3 T; TSE | N = 294; YA; OA | Semi-automatic | https://www.mpib-berlin.mpg.de/LC-Map | -- |
Keren et al., 2009 | 3 T; TSE | N = 44; YA–OA | Semi-automatic | http://www.eckertlab.org/LC | 1 SD |
Liu et al., 2019 | 3 T; MT | N = 605; YA–OA | Manual | https://osf.io/r2bwk | -- |
Tona et al. 2017 | 3 T; TSE | N = 17; YA | Manual | http://www.nitrc.org/projects/prob_lc_3t | 1 |
Ye et al., 2021 | 7 T; MT | N = 53; OA | Semi-automatic | https://www.nitrc.org/projects/lc_7t_prob | 5% prob.2 |
Note:
The masks provided by Tona and colleagues were averaged across scan sessions and segmentations.
The mask by Ye and colleagues was linearly and non-linearly co-registered from MNI-ICBM 152 non-linear 2009b to MNI-ICBM 152 linear space (0.5 mm resolution) using Advanced Normalization Tools (antsRegistration). MNI-ICBM 152 linear was chosen as target space as all but one masks share this space. For co-registration, the standard brains of the respective spaces were aligned and the transformations were applied to the mask file with a nearest neighbor interpolation. The transformations from MNI 2009b non-lin ⇔ MNI linear are shared via osf.io/sf2ky/;
T, Tesla; FLASH, Fast Long Angle Shot; TSE, Turbo Spin Echo; MT, Magnetization Transfer; YA, Younger Adults; OA, Older Adults; YA–OA, lifespan sample including younger, middle-aged and older adults; SD, standard deviation; prob., probability.