Table 2:

Descriptive statistics for imaging subgroups

	ADAD-control	ADAD-presymptomatic	ADAD-symptomatic
n	9	5	4
Mutation	0/9	5/5	4/4
Mutation type		PSEN1 (A431E; 3/5) PSEN1 (I180F; 1/5) APP (V717I; 1/4)	PSEN1 (A431E; 3/4) APP (V717I; 1/4)
Diagnosis	0/9	0/5	4/4
CASI (std, range)	95.3 (1.8; 92–97.7)	95.0 (4.2; 90–99)	74.9 (11.8; 62.8–86.8)
CDR (std, range)	0 (0, 0)	0 (0, 0)	0.75 (0.3; 0.5–1)
Age (std, range)	33.4 (12.2; 19–58)	30 (4.5; 22–33)	43.5 (1.3; 42–45)
Gender	5 male 4 female	1 male 4 female	3 male 1 female

Note: ADAD, autosomal-dominant Alzheimer’s disease; ADAD-control: control participants not carrying the mutation, but genetically related to mutation carriers; ADAD-presymptomatic: presymptomatic mutation carriers (Washington University Clinical Dementia Rating Scale [CDR] scores of 0); ADAD-symptomatic: symptomatic mutation carriers; std. standard deviation; CASI, Cognitive Abilities Screening Instrument (Teng et al., 1994); PSEN1: Presenilin-1 protein (gene); APP: Amyloid-β Precursor Protein (gene)