Table 1:
Baseline characteristics of UK Biobank participants (N=187,194) aged 60 years or older by incident dementia status (including Alzheimer’s Disease, Frontotemporal, and Vascular)
| Any Dementia (n=1,742) | No Dementia (n=185,452) | |
|---|---|---|
|
| ||
| Sociodemographic variables | Mean ± SD or N (%) | Mean ± SD or N (%) |
|
| ||
| Age (years) | 65.81 ± 2.71 | 64.10 ± 2.84 |
| Sex (Female) | 778 (44.7%) | 97,681 (52.7%) |
| College degree or higher | 311 (17.9%) | 47,462 (25.6%) |
| Income | ||
| Less than £18,000 | 627 (36.0%) | 51,083 (27.5%) |
| £18,000 to £51,999 | 573 (32.9%) | 81,257 (43.8%) |
| £Greater than £52,000 | 76 (4.4%) | 18,815 (10.1%) |
| Missing (Decline/Do not know) | 466 (26.8%) | 34,297 (18.5) |
| White (British/Irish) | 1,662 (95.9%) | 179,257 (97.0%) |
| APOE-ε4 | ||
| 0 risk alleles | 831 (47.7%) | 137,205 (74.0%) |
| 1 risk allele | 698 (40.1%) | 44,003 (23.7%) |
| 2 risk alleles | 213 (12.2%) | 4,244 (2.3%) |
| BMI (kg/m2) | 27.7 ± 5.0 | 27.6 ± 4.5 |
| Smoking Status | ||
| Never | 770 (44.2%) | 92,540 (49.9%) |
| Previous | 783 (44.9%) | 77,369 (41.7%) |
| Current | 171 (9.8%) | 14,591 (7.9%) |
| Declined | 18 (1.0%) | 952 (0.5%) |
| Urban residency | 1,640 (94.1%) | 170,925 (92.2%) |
|
| ||
| Air Pollutants (μg/m3) | Median (IQR) | Median (IQR) |
|
| ||
| PM2.5 | 9.98 (1.25) | 9.86 (1.25) |
| PM2.5–10 | 6.10 (0.76) | 6.09 (0.77) |
| PM2.5 absorbance | 1.13 (0.29) | 1.11 (0.29) |
| PM10 | 16.06 (1.74) | 15.98 (1.76) |
| NO2 | 26.72 (9.39) | 25.45 (9.47) |
| NOx | 43.04 (16.02) | 41.20 (15.88) |
Abbreviations: IQR, Interquartile range; APOE- ε4, apolipoprotein E.