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. 2022 Apr 2;12:5574. doi: 10.1038/s41598-022-09447-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Manhattan plot of common variants (MAF > 1%) associated with asthma risk in this GWAS of 3,181 moderate-to-severe asthma patients and 3590 non-asthma controls. The −log₁₀ two-sided p-values are displayed. Variants with P < 0.01 for the differential effects test (See “Methods”) are filtered out. See Supplemental Fig. S2 for a corresponding plot which includes all variants. The black line indicates the genome-wide significance threshold of 5 × 10^–8. Previously reported loci are labeled in black, the novel locus is labeled in blue.