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. 2022 Apr 2;12:5574. doi: 10.1038/s41598-022-09447-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association of polygenic scores with asthma age of onset. Childhood onset asthma was defined as age onset ≤ 12 and adult onset asthma was defined as age of onset ≥ 25. This binary age of onset trait was regressed on polygenic scores of various traits. Polygenic scores were calculated from publicly available GWAS of allergic disease (n = 242,569), asthma (n = 127,669), blood eosinophil cell counts (n = 40,521) and various lung function measures (n = 400,102). The analysis was carried out in the current whole-genome-sequencing cohort (WGS) (n = 1456) as well as in a cohort of UK Biobank participants (n = 6312). Increased polygenic scores for asthma, allergic disease and blood eosinophil counts are associated with younger age of onset, while increased lung function polygenic scores generally associate with adult onset asthma. Association statistics for PS analyses are available in Supplementary Table S7.